Twelvetrees Lab
Twelvetrees Lab
 


Welcome to the Twelvetrees Lab

The Twelvetrees Lab is a newly established research group at the University of Sheffield, based in the Sheffield Institute for Translational Neuroscience. We are fascinated by how the microtubule cytoskeleton and its motor proteins build and maintain neurons. We aim to understand the molecular mechanisms of this process and create new avenues for translational research. 

 
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Research

 

Explore our research through publications, current projects or our experimental approaches.

 

Lab life

 

Get to know us! Learn about the lab and our location, meet the team or read out latest news on the lab blog.

 

Research Images

 
EB3 comets falling in a dendritic tree.

EB3 comets falling in a dendritic tree.

Individual kinesin molecules walking along immobilised microtubules in vitro.

Individual kinesin molecules walking along immobilised microtubules in vitro.

Dynein-GFP oscillating between developing neurites imaged over 14 hours.

Dynein-GFP oscillating between developing neurites imaged over 14 hours.

Dynein-GFP (cyan) accumulating in the distal axons labelled with for tau (orange).

Dynein-GFP (cyan) accumulating in the distal axons labelled with for tau (orange).

 
It was a big week for looking at small things at the bench! Very impressed by what the Oxford Nanoimager can do. Big thanks for the team behind a great demo of a lovely scope 👍
Guess the conversation from the whiteboard scribbles...
The last few days in Sheffield have been glorious - the meadow behind SITraN has grown two feet in two weeks! #allthegreen #may
The SITraN green roof getting some tlc today; there’s usually a view beyond but we’ve been stuck in this weather for days...
Bit of a traffic jam on the way out of the building tonight
One of the feline friends who live near SITraN
Merry Christmas! See you in the new year :)
BBSRC funded PhD studentship: Analysis of neuronal kinesin-1 activation dynamics in response to cargo binding. Project Outline: We are recruiting a PhD student to work on an interdisciplinary project studying kinesin activation in the context of axonal transport and neurodegeneration. This project uses advanced single molecule imaging, biochemistry and neuronal cell biology techniques to reveal fundamental insights into motor protein regulation and axonal transport, with translational outcomes for neurodegenerative diseases. Contact Alison. See also: https://www.twelvetreeslab.co.uk/join/ https://www.findaphd.com/search/ProjectDetails.aspx?PJID=90664 Application Deadline: January 7th 2018 #science #neuroscience #neurodegeneration #phd #findaphd #phdstudentship #cytoskeleton #kinesin #microscopy #singlemoleculetracking #biochemistry #biophysics
Autumnal Firth Court with Sheffield hills in the distance.
A vey autumnal Firth Court, viewed from Western Park.